In the 1960s the molecular biology George Streisinger developed the strand-slippage hypothesis. Streisinger noticed that mutations occurred in areas of DNA that contained many repeated sequences. When a strand-slippage error occurs, an insertion mutation can result. How does the insertion mutation affect the DNA? a Nitrogenous bases are added b Nitrogenous bases are damaged. c Nitrogenous bases are exchanged. d Nitrogenous bas

George Streisinger used a bacterial virus (phage T4) to show that most insertions and deletions (indels) are due to mutations in tandem repeats. From this discovery, Streisinger proposed the strand-slippage hypothesis, which enabled to understand this process. The strand-slippage hypothesis indicates that slipped strand mispairing mutations during DNA replication may be due to DNA loops which are associated with the incorrect insertion/deletion of a nucleotide to the newly synthesized strand, and these indels can become permanent mutations.

priyankatutor priyankatutor · Answer 2 · 2021-12-07T13:23:00+01:00

The insertion mutation in which a Nitrogenous bases are added affect the DNA sequence.

Strand-slippage hypothesis:

Streisinger proposed the hypothesis which enabled to understand the process of insertion or deletion mutation. It indicates that insertion or deletion mutation occur due to the presence of sequence repeats in the DNA that results in loop formation during replication.

Therefore, the insertion mutation in which a Nitrogenous bases are added affect the DNA sequence.

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